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Research Fellow in Chemical Biology

Are you an ambitious researcher looking for your next challenge? Do you have an established background in chemical biology in its broadest sense? Do you want to further your career in one of the UKs leading research intensive universities?

As Research Fellow in Chemical Biology you will join a BBSRC-funded team focused on developing and exploiting new tools to understand and perturb protein-protein interactions (PPIs) involving intrinsically disordered regions. You will assist the Investigators in delivering this large research programme by focussing on the design and synthesis of small-molecule chemical probes for disease relevant PPIs, with considerable emphasis on targets in oncology.

The post is associated with a major £5.4 million five-year collaborative research programme led by Professor Andy Wilson, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), and bringing together the University of Leeds, the University of Oxford, and project partners, AstraZeneca and LifeArc. This large and diverse programme focuses on Deciphering the function of intrinsically disordered protein regions in a cellular context using The Aurora A kinase (Aurora A) as a target. Aurora A represents a key potential target for anticancer therapeutics development and plays a fundamental role in regulating cell division.The specific purposes of the role are to (i) develop reagents capable of inhibiting the interactions of Aurora A, (ii) use proteomics methods to dissect the cellular interactome of Aurora A.

You will be part of a large team based in The Wilson, and The Wright groups in the School of Chemistry and the Astbury Centre for Structural Molecular Biology with access to a superb infrastructure for research in chemical biology, including synthetic laboratories, NMR equipment, X-ray crystallographic, mass spectrometry and biophysical techniques, together with state of the art online resources.

You will have a PhD (or have submitted your thesis prior to starting) in an area appropriate to the project, along with extensive knowledge of chemical proteomics and/or chemical probe development.


To explore the post further or for any queries you may have, please contact: 

Andrew Wilson, Professor of Organic Chemistry 

Tel: +44 (0)113 343 1409 or email: A.J.Wilson@leeds.ac.uk 


How to apply

Your application should include the following as attachments:

  • a supporting statement providing evidence to support each requirement listed on the ‘What will you bring to the role’ section of the Candidate Brief (no more than 2 sides of A4, minimum font size 11); and

  • an academic curriculum vitae, including a list of your publications.


Further information  

The Schools in the Faculty of Engineering & Physical Sciences are proud to have been awarded the Athena SWAN Bronze or Silver Award from the Equality Challenge Unit, the national body that promotes equality in the higher education sector. Our equality and inclusion webpage provides more information.


Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Engineering & Physical Sciences
School/Institute:  School of Chemistry
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Working Time:  37.5 hours per week
Post Type:  Full Time
Contract Type:  Fixed Term (3 years due to grant funding)
Release Date:  Wednesday 21 October 2020
Closing Date:  Sunday 22 November 2020
Interview Date:  To be confirmed
Reference:  EPSCH1022
Downloads:  Candidate Brief  

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

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Athena Swan Bronze Award
Equality and Inclusion - Everyone Included, Everyone Involved
HR Excellence in Research