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Research Fellow in Biochemistry/Biophysics

Are you looking to apply your skills in Biochemistry/Biophysics to help gain a new molecular understanding of how proteins assemble into amyloid fibrils and help to develop new routes to understand the molecular origins of memory formation and memory loss in disease?

We are looking for an outstanding research fellow to join a well-established interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils and cause disease. This Royal Society-funded post-doctoral fellowship aims to determine the mechanisms of amyloid formation in vitro, in cells and in model organisms. You will focus on two contrasting protein systems, one involved in neurodegeneration associated with Parkinson’s disease (-synuclein (Syn)), and the second, a functional amyloid (CPEB/Orb2), involved in the formation and storage of long-term memories. Specifically, you will exploit recent advances in biophysical methods, and combine them with structural methods, chemical biology and other approaches, to map the transient protein-protein interactions that drive amyloid formation, to map the dynamic regions of fibrils, and to understand the interactions of fibrils in cells. The outcome will be a transformation in our understanding of how amyloid fibrils create memory, and new opportunities to target the dynamic interactome of amyloid fibril assemblies for human benefit.

You will be based in the laboratory of Professor Sheena Radford. You will have a PhD (or be close to completion) in Chemistry, Biochemistry, Biophysics or a related discipline. You will also have experience of using biophysical and biochemical methods to analyse protein structure and assembly and protein interactions. Experience in the use of biophysical methods to analyse protein dynamics and/or protein interactions in vitro and in cells would be an advantage.

To explore the post further or for any queries you may have, please contact:

Sheena E Radford, Astbury Professor of Biophysics  Tel: +44 (0)113 343 3170  Email:

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Due to funding restrictions it is unlikely an appointment will be made above £34,804
Working Time:  37.5 hours per week
Post Type:  Full Time
Contract Type:  Fixed Term (3 years)
Release Date:  Thursday 26 August 2021
Closing Date:  Saturday 25 September 2021
Reference:  FBSAS1044
Downloads:  Candidate Brief  
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