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Research Fellow

Are you an ambitious researcher looking for your next challenge? Do you have an established background in Biochemistry or Structural Biology? Do you want to further your career in one of the UKs leading research intensive Universities?

This position is to study the dynamics and catalysis integral membrane pyrophosphatases, aiming to determine how they pump both sodium ions and protons, to determine the mechanism (alternating or both ions pumped through a single chain at once) of this and of gate opening, and to use this as the basis for drug design.  It builds on recent work published in Nature Communications and Science Advances (Vidilaseris, K. et al. & Goldman, A. Sci Adv 5, eaav7574 (2019); Li K-M. et al. & Goldman, A. Nat Commun 7, 13596 (2016)). The project combines protein production and purification with crystallisation, crystallography and electrophysiological measurements to determine the structure and mechanism of this challenging system.

You will work in the multidisciplinary School of Biomedical Sciences (SBMS), which includes biochemists and physicists, and as part of the Astbury Centre for Structural Molecular Biology.  You will be supervised by Professor Adrian Goldman (SBMS), and the work will involve close collaboration with the groups of Professor Lars Jeuken and Dr. Christos Pliotas (SBMS), and Dr. Antreas Kalli (Faculty of Medicine and Health).

You will be a highly motivated individual with a strong basis in structural biology, and experience in working with membrane proteins.  You should have a PhD (or be close to completion) in Biochemistry, Structural Biology or a closely allied discipline and have previous experience in membrane protein expression and purification, x-ray crystallography or cryo-electron microscopy. Experience in lipid assays, eukaryotic tissue culture, EPR, FRET and/or Molecular dynamics simulations would be desirable.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was reawarded a Bronze award in 2017.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information. 

To explore the post further or for any queries you may have, please contact: 

Adrian Goldman, Professor in Membrane Biology

Tel: +44 (0)113 343 8537, Email: A.Goldman@leeds.ac.uk

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Biomedical Sciences
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Due to funding limitations it is unlikely an appointment will be made above £35,845
Working Time:  37.5 hours per week
Post Type:  Full Time
Contract Type:  Fixed Term (36 Months)
Release Date:  Thursday 19 December 2019
Closing Date:  Saturday 18 January 2020
Interview Date:  Thursday 30 January 2020
Reference:  FBSBM1137
Downloads:  Candidate Brief  

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

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