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Research Fellow in Structure-based Cancer Drug Discovery and Biophysics

Are you an ambitious researcher looking for your next challenge? Do you have an established background in structural biology and biophysical methods, including X-ray crystallography and/or NMR spectroscopy? Do you want to further your career in one of the UKs leading research intensive Universities?

Based in the laboratory of Professor Alex Breeze in the Astbury Centre for Structural Molecular Biology and in collaboration with partners based in Leeds (Dr Darren Tomlinson) and at Newcastle University (Professor Mike Waring, Department of Chemistry) you will work on the design of allosteric inhibitors of the Ras exchange factor, SOS. 

The project is funded for 2 years by Cancer Research UK (CRUK) and will involve fragment-based compound screening and structural analysis using X-ray crystallography, together with analysis of binding interactions by NMR, biophysical and computational methods. You will then take optimised compounds forward into cell-based assays. Exceptional facilities are available in Leeds to support the project, including state-of-the-art X-ray crystallography and biophysics infrastructure and a new, 950 MHz cryoprobe-equipped NMR spectrometer.

To apply, you should be a highly multidisciplinary and collaborative Postdoctoral Researcher who has a PhD (or close to completion) in structural biology (preferably with a focus on X-ray crystallography) and has experience in the use of other structural and biophysical methods (e.g. NMR, SPR, ITC, thermal melt/DSC, MST).

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was reawarded a Bronze award in 2017.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information. 

To explore the post further or for any queries you may have, please contact: 

Professor Alex Breeze, Professor of Biomolecular NMR, Tel: +44 (0)113 343 0087, Email:

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Molecular & Cellular Biology
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.
Due to funding restrictions there is a maximum salary of £36,914 for this post
Working Time:  37.5 hours per week
Post Type:  Full Time
Contract Type:  Fixed Term (2 years available from 1 January 2020)
Release Date:  Tuesday 05 November 2019
Closing Date:  Tuesday 19 November 2019
Reference:  FBSMB1168
Downloads:  Candidate Brief  

The closing date for this job opportunity has now passed, and applications are no longer being accepted for this position

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Athena Swan Bronze Award
Equality and Inclusion - Everyone Included, Everyone Involved
HR Excellence in Research