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Research Fellow

We are looking for a highly motivated postdoctoral research fellow to join a team of researchers investigating the structural basis of hypertrophic cardiomyopathy, an inherited heart disease that affects more than 1 in 500 people. Most mutations resulting in disease are found in either β-cardiac myosin heavy chain or cardiac myosin-binding protein-C (cMyBP-C) yet the link between mutation and disease outcome is poorly characterised. By use of an integrative structural biology approach this research project will unravel structural-functional relationships between β-cardiac myosin and cMyBP-C and the impact of disease mutation on those relationships. The project will use a combination of electron microscopy (negative-stain and cryo), structural mass spectrometry, biochemistry, biophysics, molecular modelling and cell biology methods to achieve this.

You should have a PhD (or be close to completion) in Structural Biology, Biochemistry, Biophysics or a related discipline. You should have experience in the analysis of macromolecular structure using either structural mass spectrometry methods (e.g. native mass spectrometry, chemical crosslinking, covalent footprinting and/or hydrogen-deuterium exchange), and/or cryo-electron microscopy, and complementary biophysical methods (e.g. circular dichroism, SDSPAGE). You should also have experience in protein production.

You will be based in the laboratory of Dr Charlie Scarff (BHF Intermediate Fellow) and will work closely with collaborators at Leeds (Dr James Ault, Dr Sarah Harris and Prof. Michelle Peckham), across the UK and internationally (Prof. Howard White, EVMS and Prof. Donald Winkelmann, Rutgers). You will join the vibrant LICAMM and Astbury Centre communities and benefit from the world-leading facilities we have in the Astbury Biostructure Laboratory (two Titan Krios microscopes) and Mass Spectrometry Facility (dedicated HDX-MS system, UHMR Q-Exactive and Orbitrap Exploris).

To explore the post further or for any queries you may have, please contact:

Dr Charlie Scarff, BHF Jacqueline Murray Coomber Fellow

Email: C.A.Scarff@leeds.ac.uk 

As an international research-intensive university, we welcome students and staff from all walks of life. We foster an inclusive environment where all can flourish and prosper, and we are proud of our strong commitment to student education.  Within the School of Medicine we are dedicated to diversifying our community and we welcome the unique contributions that individuals can bring, and particularly encourage applications from, but not limited to Black, Asian, people who belong to a minority ethnic community; people who identify as LGBT+; and disabled people. Candidates will always be selected based on merit and ability. 

 

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Medicine & Health
School/Institute:  Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM)
Section:  Discovery and Translational Science Department (DTSD)
Category:  Research
Grade:  Grade 7
Salary:  £35,333 to £42,155 per annum
Post Type:  Full Time
Contract Type:  Fixed Term (2 years due to external funding, 1 February 2023 to 31 January 2025)
Release Date:  Tuesday 03 January 2023
Closing Date:  Tuesday 31 January 2023
Reference:  MHLCM1316
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Athena Swan Bronze Award
Equality and Inclusion - Everyone Included, Everyone Involved
HR Excellence in Research