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Research Fellow

Overview of the Role

This new and exciting position is funded by the British Heart Foundation and will enable us to extend our studies on the functions and regulations of Piezo1 mechanosensitive channel. Piezo1 channel is a critical mechanical sensor in endothelial cells, red blood cells and other cell types such as cardiac fibroblasts. Mutations on Piezo1 have been shown to result in a number of cardiovascular diseases. Building a detailed molecular and dynamic understanding of Piezo1, which will complement the available functional and regulatory data, will fill an important gap in our understanding of the functions and regulations of this biologically important channel.

You will use modelling and simulation tools to perform molecular dynamics simulations of Piezo1 channel in complex model membranes both at the coarse-grained and atomistic resolution. These simulations will facilitate us to address key questions about the regulatory mechanism of Piezo1 by important endogenous substances. You will work in the group of Dr Jian Shi at the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), and the work will involve close and interactive collaboration with the groups of Dr Antreas Kalli, Prof David Beech and Prof Lee Roberts within LICAMM.

Main Duties and Responsibilities

As Research Fellow your main duties will include:

  • Performing and analysing the molecular modelling and molecular dynamics simulations of the Piezo1 channel to meet the main aims of the study;
  • Generating and pursuing original research ideas in the appropriate subject area;
  • Developing research objectives and proposals and contributing to setting the direction of the research project and team including, where appropriate preparing proposals for funding in collaboration with colleagues;
  • Evaluating methods and techniques used and results obtained by other researchers and to relate such evaluations appropriately to your own work;
  • Communicating or presenting research results through publication or other recognised forms of output;
  • Preparing papers for publication in leading international journals and independently writing reports;
  • Collaborating effectively with experimental collaborators and with other research groups within Leeds and elsewhere to ensure the production of robust and high quality research;
  • Working both independently and also as part of a larger team of researchers, engaging in knowledge-transfer activities where appropriate and feasible;
  • Maintaining your own continuing professional development and acting as a mentor to less experienced colleagues as appropriate;
  • Contributing to the research culture of the School, where appropriate;
  • Contributing to the training of both undergraduate and postgraduate students, where appropriate, including assisting with the supervision of projects in areas relevant to the project.

These duties provide a framework for the role and should not be regarded as a definitive list. Other reasonable duties may be required consistent with the grade of the post.

To explore the post further or for any queries you may have, please contact:

Jian Shi, Associate Professor



Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Medicine & Health
School/Institute:  Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM)
Section:  Discovery and Translational Science Department (DTSD)
Category:  Research
Grade:  Grade 7
Salary:  £35,333 to £42,155 per annum
Post Type:  Full Time
Contract Type:  Fixed Term (18 months, 11 July 2023 to 10 January 2025 - due to external funding)
Release Date:  Thursday 19 January 2023
Closing Date:  Thursday 23 February 2023
Reference:  MHLCM1319
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Athena Swan Bronze Award
Equality and Inclusion - Everyone Included, Everyone Involved
HR Excellence in Research